Who among us does not suffer from pain or did not feel pain in different parts of the body such as the head, joints, etc. But many of us are unaware of how to feel the pain, which represents a warning signal from the person’s brain and indicates a defect in the part in which the person feels pain.
Sensory nerves are found in the skin and other parts of the body and its importance lies in transmitting the feeling through the conductors of electrical charges of the central nervous system. The brain translates these vectors and stimuli to feel pain, pressure, itching and other reactions.
Prostaglandins are proteins and neurotransmitters, which are proteins that are excreted from cells when they malfunction and are responsible for stimulating pain, and the production of other proteins involved in the inflammatory reactions that increase the feeling of pain.
The fact that the feeling of pain is undesirable when a lot of people should be treated and disposed of, and here was Ttaiwirmesknat pain including treatment ( paracetamol).
Paracetamol, or Acetaminophen, has been in our hands for 50 years and is the first and most secure option as a pain reliever and hypothermic, and it was manufactured in several forms that suit different age groups. As for the principle of the work of paracetamol in the human body, it is not entirely clear to our present time, but many indicated From scientific studies and research to its effectiveness as follows:
* As an antinociceptive, it prevents certain vectors responsible for pain in the central nervous system, known as prostaglandins.
* It works to prevent the formation and eruption of pain in the peripheral nervous system before it reaches the central nervous system.
As for its antipyretic, it affects the hypothalamus region known as the hypothalamus in the brain.
There are many international studies and research on how paracetamol works in the body and how to get rid of pain, among them:
The first study demonstrated that paracetamol works to inhibit prostaglandin synthesis from healthy cells. This study was conducted on rheumatic albumin cells from the human body, but it did not explain the selectivity of paracetamol to it.
The second study demonstrated that paracetamol is based on inhibition of prostaglandins resulting from stellar brain cells resulting from the stimulation of beta-amyloid protein in nerve cells.
The third study proved that paracetamol works to inhibit prostaglandin E2 in macrophages in the brain, which makes it an appropriate option when developing cerebral infections.
Finally, a study indicated that the concentration of paracetamol is higher in cerebrospinal fluid compared to blood plasma, which proves the action of paracetamol in the central nervous system as a pain reliever.